dihexa structure | c-Met chemical | CAS 1401708-83-5 Dihexa isn't a stimulant. It's

MariTide Phase 2 Obesity Trial Investigators

Ruseva, A

A method of preventing dementia in a patient with Parkinson's disease or of improving or restoring cognitive function of a patient with Parkinson's disease, comprising the step of administering to said patient an amount of one or more hepatocyte growth factor mimics sufficient to prevent, improve or restore to normal said cognitive function, said one or more hepatocyte growth factor mimics having a general structural formula 1 2 3 where Ri is one of an N-acyl group, a substituted or unsubstituted phenyl, a norleucine group, and an amino acid selected from tyrosine, phenylalanine, aspartic acid, arginine, isoleucine, serine, histidine, glycine, cysteine, methionine, tryptophan, lysine norvaline, ornithine, and s-benzyl cysteine

Aged animals typically exhibit difficulty with spatial learning tasks, yet Dihexa treatment enabled these older rats to perform at levels comparable to young animals, suggesting the compound's capacity to restore age-compromised cognitive function

"The procognitive and synaptogenic effects of angiotensin IV-derived peptides are dependent on activation of the hepatocyte growth factor/c-met system." Journal of Pharmacology and Experimental Therapeutics

Rats treated with TPPU spent more time (33 2 s) in the target quadrant of the water maze which is a result of development in sporadic memory